PLoS Biology - A Computational Framework for Ultrastructural Mapping of Neural Circuitry

PLoS Biology - A Computational Framework for Ultrastructural Mapping of Neural Circuitry: "Building an accurate neural network diagram of the vertebrate nervous system is a major challenge in neuroscience. Diverse groups of neurons that function together form complex patterns of connections often spanning large regions of brain tissue, with uncertain borders. Although serial-section transmission electron microscopy remains the optimal tool for fine anatomical analyses, the time and cost of the undertaking has been prohibitive. We have assembled a complete framework for ultrastructural mapping using conventional transmission electron microscopy that tremendously accelerates image analysis."